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Lewis-Sigler Institute for Integrative Genomics
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News

Coleen Murphy awarded McKnight Scholar Award
5/13/2008 - Coleen Murphy, an Assistant Professor of Molecular Biology and member of the Lewis-Sigler Institute for Integrative Genomics is the recipient of a McKnight Endowment Fund for Neuroscience Scholar Award. The Awards, which provide research support for three years, encourage neuroscientists in the early stages of their careers to focus on disorders of learning and memory. Dr. Murphy's research project is entitled "Molecular Characterization of Long-Term Memory Maintenance with Age."

Lewis-Sigler Institute faculty member Joshua Shaevitz receives Human Frontier Science Program Award
4/1/2008 - Joshua Shaevitz, an Assistant Professor in physics and the Lewis-Sigler Institute for Integrative Genomics, along with his collaborator Tâm Mignot at the IBSM- Structural Biology and Microbiology Institute in Marseilles, France, has been awarded a Young Investigators' research grant from the Human Frontier Science Program. The award funds collaborative research that actively involves all members of the team, providing $250,000 per year for three years. Their research proposal is entitled "Biophysics of bacterial gliding motility".

Susan Powell wins President's Achievement Award
3/27/08 - Lewis-Sigler Institute Assistant Director Susan M. Powell is the recipient of a University President's Achievement Award [http://www.princeton.edu/hr/recog/paawinners.htm]. The Award recognizes members of the support and administrative staff with five or more years of Princeton University service whose dedication and special efforts have contributed significantly to the success of their departments and the University. In his nomination, David Botstein, the Anthony B. Evnin '62 Professor of Genomics and director of the institute, wrote, "Susan has earned the respect and admiration of everybody in the institute. She is the person to whom almost anyone will turn first. She has been very creative in thinking of ways to fund, for instance, research and teaching infrastructure, and has contributed many of the ideas that ultimately have been accepted by funders. She has managed funds flexibly and fairly, so that we have gotten more out of each dollar as a result. Susan is an all-around outstanding administrator, and deserves extraordinary recognition for an extraordinary level of excellence and innovation in her work."

Lewis-Sigler Institute faculty member Joshua Shaevitz receives Sloan Research Fellowship
2/18/2008 - Joshua Shaevitz, an Assistant Professor in physics and the Lewis-Sigler Institute for Integrative Genomics, has been awarded a Sloan Research Fellowship by the Alfred P. Sloan Foundation. The Sloan Fellowship is an unrestricted grant awarded to outstanding scientists and scholars early in their careers. He will use his two-year grant of $45,000 to fund research on the physical mechanisms of cell shape in bacteria.

Coleen Murphy awarded a March of Dimes Basil O'Connor Starter Scholar Award
1/7/2008 - Coleen Murphy, an Assistant Professor of Molecular Biology and member of the Lewis-Sigler Institute for Integrative Genomics has been awarded a March of Dimes Basil O'Connor Starter Scholar Award. The awards support research on birth defects by young scientists just embarking on independent research careers. The goal of Dr. Murphy's proposed research is to identify genetic and molecular mechanisms that maintain oocyte quality with age.

Coleen Murphy featured in Princeton Alumni Weekly article
12/3/2007 - Coleen Murphy, an Assistant Professor of Molecular Biology and member of the Lewis-Sigler Institute for Integrative Genomics, is the subject of a Breaking Ground column in the November 21, 2007 Princeton Alumni Weekly. The article describes how Murphy's lab studies biological processes that decline before death in C. elegans. Learning about the genes that govern those activities in worms could help to identify analogous genes in humans.

Leonid Kruglyak selected to appear on ISIHighlyCited.com
11/15/2007 - Leonid Kruglyak, Lewis-Sigler Institute member and Professor of Ecology and Evolutionary Biology has been selected to appear on ISIHighlyCited.com because of his exceptional citation count in the field of Molecular Biology & Genetics. Less than one half of one percent of all publishing authors meet the criteria for inclusion on the website.

William Bialek and David Tank featured in a Princeton Weekly Bulletin article
11/12/2007 - Two Lewis-Sigler Institute faculty members have been featured in a Princeton Weekly Bulletin article titled "Together to fly: Age-old question pushes scientists to step beyond their fields - into each other's." The article describes how William Bialek and David Tank worked with Molecular Biology faculty member Eric Wieschaus, and Bialek's then-graduate student Thomas Gregor, to study how a fly's embryonic cells determine their ultimate function in the adult fly, drawing on the fields of biology and physics. The interdisciplinary project yielded valuable information on signaling in embryonic development and led to two papers in the Journal Cell. (Read more.)

Leonid Kruglyak elected a Fellow of the American Association for the Advancement of Science
10/23/2007 - Leonid Kruglyak, Lewis-Sigler Institute member and Professor of Ecology and Evolutionary Biology has been elected a Fellow of the American Association for the Advancement of Science. Election as a Fellow is an honor bestowed upon members by their peers. Fellows are recognized for meritorious efforts to advance science or its applications. Dr. Kruglyak's citation is for "distinguished contributions to the study of variation in the human genome and for pioneering genetic studies of gene expression variation." (Read more.)

Manuel Llinás receives an NIH Director's New Innovator Award.
9/18/2007 - Manuel Llinás, Lewis-Sigler Institute Member and Assistant Professor of Molecular Biology, has been selected to receive an NIH Director's New Innovator Award. The award provides $1.5 million in support over five years, and will be used to define how metabolic pathways in the malaria-causing organism interact with human cell pathways, as a means of discovering new targets for treatment. (Read more.)

Manuel Llinás receives a Burroughs Wellcome Investigators award.
5/11/2007 - Manuel Llinás, Lewis-Sigler Institute Member and Assistant Professor of Molecular Biology, has been selected to receive a Burroughs Wellcome Investigators in Pathogenesis of Infectious Disease Award for Research. The award provides $500,000 of support, over five years, for U.S. and Canadian Scientists at the Assistant Professor Level. Dr. Llinás's research will focus on a global analysis of the Plasmodium falciparum metabolome, and will investigate the metabolic aspect of host-pathogen interactions in the malaria-causing parasite Plasmodium falciparum as a means to identify novel drug targets.

New Integrated Science Website launched by Lewis-Sigler Institute
4/12/2007 - A new website has been launched for the Institute's Integrated Science curriculum, describing the concept and advantages of this multidisciplinary curriculum. The Integrated Science sequence is suitable for any undergraduate considering concentrating in the sciences or engineering at Princeton. The core training covers introductory physics, chemistry, biology, and computer science, all in an integrated manner. The central role of mathematics as a universal language of science is emphasized throughout. In the courses, collaborative problem solving is stressed over memorization and regurgitation of facts. Close contact between students and faculty is a major feature of the new curriculum; class sizes are kept small.

Integrated Science curriculum featured in Princeton Weekly Bulletin
3/15/2007 - The Integrated Science curriculum, a joint effort by the Institute and affiliated science departments, is the subject of a feature article in the March 12 issue of the Princeton Weekly Bulletin. The article, "Testing the boundaries of teaching science", discusses the challenges and rewards of the three-year-old effort to dramatically reorganize the manner in which scientific ideas are introduced to students.

Josh Rabinowitz featured in Princeton Weekly Bulletin
1/8/2007 - Josh Rabinowiz, Lewis-Sigler Institute member and Assistant Professor in Chemistry, is the subject of a feature article in the January 8 issue of the Princeton Weekly Bulletin. The article discusses Rabinowitz's dual scientific background in both the industrial and academic worlds and his current research at Princeton. (Read more)

David Tank Awarded Spencer Medal
10/9/2006 - David Tank, a Lewis-Sigler Institute member and Henry L. Hillman Professor in Molecular Biology, who is also Co-director of the Program in Neuroscience and the Princeton Neuroscience Institute, received the Alden Spencer Award from The Center for Neurobiology and Behavior at Columbia University on September 29. Professor Winifred Denk of the Max Planck Institute was a co-recipient. Dr. Tank's lecture "Persistent Activity in Neural Integrators" was followed by the awards ceremony. The Alden Spencer Award is given each year by the College of Physicians and Surgeons in recognition of outstanding research contributions in neural science.

Institute Director David Botstein's presentation to NIGMS.
9-15-2006 - Institute Director David Botstein recently made a presentation at the National Institute of General Medical Sciences Council in Bethesda Maryland as the Co-Principal Investigator of Princeton's NIGMS/NIH-funded Center for Quantitative Biology. His presentation, "Center for Quantitative Biology at Princeton: Infrastructure for Research and Teaching," is available as a PowerPoint presentation (16.4 MB) or a PDF file (50.8 MB).

Coleen Murphy is named a 2006 Pew Scholar.
06-22-2006 - Coleen Murphy, an Assistant Professor of molecular biology and member of the Lewis-Sigler Institute for Integrative Genomics, has been named a 2006 PEW Scholar in the Biomedical Sciences, one of fifteen promising early- to mid-career biomedical researchers in the nation to be honored. The grants are awarded by The Pew Charitable Trusts and the University of California at San Francisco (UCSF). Each Scholar will receive $240,000 over four years to undertake research on a biomedical science project of their choosing.

Professor Murphy also received the Sloan Fellowship earlier this year, as well as an Ellison Medical Foundation Award, which she will relinquish in order to accept the PEW. Her long-term research objective is to discover the molecular basis of aging by studying the genetic pathways that determine longevity. (Read more).

Olga Troyanskaya Receives Howard Wentz Award.
6/9/2006 - Olga Troyanskaya, assistant professor of computer science, won the Howard Wentz Award. Troyanskaya joined the Princeton faculty in 2003 and holds a joint appointment in the Lewis-Sigler Institute for Integrative Genomics. She works at the intersection of molecular biology and computer science, developing computational methods for the analysis of gene expression data. Her work has led to the identification of multiple chromosomal changes in biopsies of breast cancer patients. The full story of the event can be found here.

William Bialek receives one of four President's Awards for Distinguished Teaching.
6/6/2006 - William Bialek, the John Archibald Wheeler/Battelle Professor in Physics and Lewis-Sigler Institute faculty member, is one of four Princeton faculty members receiving the President's Awards for Distinguished Teaching at Commencement ceremonies June 6.

Bialek is one of the architects of the Institute's new integrated science curriculum for undergraduates, which involves faculty from chemistry, computer science, molecular biology and physics. (Read more.)

Coleen Murphy receives an Ellison Medical Foundation New Scholars in Aging award.
6/5/2006 - Coleen Murphy, an Assistant Professor in molecular biology and the Lewis-Sigler Institute for Integrative Genomics, has been awarded an Ellison Medical Foundation New Scholars in Aging award. The Ellison Medical Foundation Aging Program supports basic biomedical research on aging relevant to understanding aging processes and age-related diseases and disabilities. The award is $50,000 per year over four years. Murphy's long-term objective is to discover the molecular basis of aging by studying the genetic pathways that determine longevity.

Curtis Huttenhower receives an Association of Princeton Graduate Alumni (APGA) Teaching Award
5/18/2006 - Curtis Huttenhower, a Department of Computer Science Graduate Student in Institute faculty member Olga Troyanskaya's lab, has been awarded an Association of Princeton Graduate Alumni (APGA) Teaching Award for his work as an Assistant in Instruction for CHM/COS/MOL/PHY 231-234, the freshman integrated science course organized by the Institute. The APGA and the Friends of the International Center fund a competition each year to recognize and honor those graduate students who have made a significant contribution to undergraduate teaching. Mr. Huttenhower was nominated by his department, supported by his students and, along with four other AIs, chosen by the Teaching Award Selection Committee for this distinction.

Faculty Member Manuel Llinás is Awarded a Young Investigator grant.
3/28/2006 - The Arnold and Mabel Beckman Foundation has awarded Institute and Molecular Biology Faculty member Manuel Llinás a $264,000 Young Investigator grant for his work, "Identifying key regulators of the Plasmodium falciparum transcriptome using whole-genome approaches."

Each year the Beckman Foundation also sponsors a symposium, which highlights the work of four classes of Beckman Young Investigators. The symposium will be held at the Beckman Center of the National Academies of Sciences and Engineering in Irvine, California in late August.

Institute researchers develop faster, inexpensive way to sequence genes
3/9/2006 - A group of Institute researchers have developed a new straightforward, cost-effective sequencing method that is providing key data in days rather than months. The approach, described in the March 9 issue of Science, involves using a new type of microarray and innovative computational techniques to compare sequences and identify subtle differences between genomes. (Read more)

Lewis-Sigler Institute faculty member Coleen Murphy receives Sloan Research Fellowship
2/24/2006 - Coleen Murphy, an Assistant Professor in molecular biology and the Lewis-Sigler Institute for Integrative Genomics, has been awarded a Sloan Research Fellowship by the Alfred P. Sloan Foundation. The Sloan Fellowship is an unrestricted grant awarded to outstanding scientists and scholars early in their careers. She will use her two-year grant of $45,000 to fund investigations into the maintenance of neuronal function during aging using the model system C. elegans. Because much of the genome (85%) of C. elegans is shared with humans, this work could eventually result in treatments for aging- and aging-disease-associated neurodegenerative disorders.

Lewis-Sigler Institute faculty member Olga Troyanskaya receives NSF CAREER Award
2/6/2006 - Olga Troyanskaya, an Assistant Professor of computer science and the Lewis-Sigler Institute for Integrative Genomics, has been awarded an NSF CAREER Award by the The National Science Foundation. She will use her award of $1,000,692 over five years to combine computational and experimental techniques for analyzing networks of biological processes within organisms. The CAREER program, NSF's most prestigious grants for scientists early in their careers, supports young, tenure-track "teacher-scholars who most effectively integrate research and education within the context of the mission of their organization." The grants are intended to "build a firm foundation for a lifetime of integrated contributions to research and education." (Read more: http://www.princeton.edu/main/news/archive/S13/95/36K00/index.xml?sectio n=announcements)

Lewis-Sigler Institute faculty member Manuel Llinás wins American Society for Microbiology award
11/21/05 - The American Society for Microbiology and the American Academy of Microbiology have selected Institute faculty member Manuel Llinás as one of two recipients of the 2006 Merck Irving S. Sigal Memorial Award from the American Society of Microbiology. The awards recognize and reward excellence in basic research in medical microbiology and infectious disease. They are presented in memory of Irving S. Sigal, who was instrumental in the early discovery of therapies to treat HIV/AIDS.

Lewis-Sigler Institute faculty member David Tank to co-direct new neuroscience institute
11/16/2005 - Princeton University is expanding its teaching and research capabilities in neuroscience -- considered by many the next field ripe for significant scientific breakthroughs -- by launching an institute that will bridge many disciplines and take a new approach to studying the brain and nervous system. The new endeavor will be co-directed by Jonathan Cohen, the Eugene Higgins Professor of Psychology, and David Tank, the Henry Hillman Professor in Molecular Biology, who has a joint appointment in physics and who is also a member of the Lewis-Sigler Institute (read more).

Lewis-Sigler Institute launches QCB @ Princeton website for Graduate Program
10/06/05 - The Lewis-Sigler Institute encourages prospective Princeton University graduate students to consider the multi-discliplinary program in Quantitative and Computational Biology (QCB). The program provides graduate education at the interface of biology with the physical and computational sciences. QCB currently includes five actively participating departments: Chemistry, Computer Science, Ecology and Evolutionary Biology, Molecular Biology and Physics. A total of 70 faculty representing 12 departments have joined the program. Ph.D. degrees will be offered by the collaborating academic departments with some indication of the interdisciplinary nature of the thesis.

John Hopfield earns Einstein World Award of Science
08/11/05 - John Hopfield, an endowed professor of molecular biology and the Lewis-Sigler Institute for Integrative Genomics, has been selected to receive the 2005 Albert Einstein World Award of Science by the World Cultural Council. This award is given in recognition of an outstanding contribution to a discipline within the sciences that has benefited humanity. Hopfield is being recognized for his contributions to three major disciplines --- physics, chemistry and biology and for his ability to cross disciplines "to discover new questions and propose answers that uncover the conceptual structure behind the experimental facts." The award will be conferred at a ceremony hosted by the Universidad Autonoma Agraria Antonio Narro in Saltillo, Coahuila, Mexico on November 12th.(read more)

Matthew Hibbs receives an Association of Princeton Graduate Alumni (APGA) Teaching Award
5/10/2005 - Matthew Hibbs, a Department of Computer Science Graduate Student in Institute faculty member Olga Troyanskaya's lab, has been awarded an Association of Princeton Graduate Alumni (APGA) Teaching Award for his work as an Assistant in Instruction for CHM/COS/MOL/PHY 231-234, the new freshman integrated science course organized by the Institute. The APGA and the Friends of the International Center fund a competition each year to recognize and honor those graduate students who have made a significant contribution to undergraduate teaching. Mr Hibbs was nominated by his department, supported by his students and, along with four other AIs, chosen by the Teaching Award Selection Committee for this distinction.

Joshua Rabinowitz receives a Beckman Young Investigators Grant
04/13/2005 - Joshua D. Rabinowitz, an assistant professor in chemistry and the Lewis-Sigler Institute for Integrative Genomics, has been awarded an Arnold and Mabel Beckman Foundation Young Investigators grant. His research project, "Towards a Holistic Understanding of Cellular Metabolism," is one of twenty-four chosen from a national field of candidates for support over the next three years. The Beckman Young Investigators (BYI) Program is intended to provide research support to the most promising young faculty members in the early stages of academic careers in the chemical and life sciences.

Olga Troyanskaya receives a Sloan Research Fellowship
Olga Troyanskaya, an assistant professor in computer science and the Lewis-Sigler Institute for Integrative Genomics, is among 116 U.S. researchers chosen by the Alfred Sloan Foundation to receive a Sloan Research Fellowship. The Sloan Fellowship is an unrestricted grant awarded to outstanding scientists and scholars early in their careers. (read more)

James Broach Appointed to New Jersey Commission on Cancer Research
Molecular Biology Professor and Associate Chair James Broach joined the New Jersey Commission on Cancer Research (NJCCR). The NJCCR's mission is to ensure that New Jersey residents receive the fullest benefit of our nation's fight against cancer through the promotion and funding of research into the causes, prevention, and treatment of cancer. To date, the NJCCR has provided over $25 million in funding to more than 550 research projects focused on cancer.

John Hopfield Elected American Physical Society Vice President
John Hopfield, the Howard A. Prior Professor of Molecular Biology, was elected as the new American Physical Society vice president by APS members. Hopfield will serve as vice president during 2005, as president-elect in 2006, and in 2007 will assume the role of President.

The American Physical Society is active in public and governmental affairs, and in the international physics community. The Society also conducts programs in education, public outreach, and media relations. The APS has 43,000 members and in 2005 will take a lead role in US participation in the World Year of Physics.

A New Center for Quantitative Biology at Princeton.
NIH is funding a new multidisciplinary initiative, called the Center for Quantitative Biology, which will be headed by David Botstein, director, and Jim Broach, associate director of the Lewis-Sigler Institute for Integrative Genomics. The new research center will focus mainly on using advanced computational methods to study complex biological systems.

First release of a web-based generic Gene Ontology (GO) Term Finder
The Bioinformatics group at the Lewis-Sigler Institute has just released a web-based generic ("multi-organism") GO Term Finder. This generic GO Term Finder web tool finds significant GO terms shared among a list of genes from your organism of choice, helping you discover what these genes may have in common. For a list of additional Gene Ontology Tools, please visit the GO Tools page.

New online resource, the Princeton MicroArray database
University researchers and their collaborators can now register for use of the Princeton University MicroArray database (PUMAdb). This web resource facilitates data management, result analysis, and collaborative research projects.



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